The domaine owes its name to Cesare Pio, one of the first people to have faith in the potential of Piedmont appellations such Barolo, Barbaresco and Barbera. In the late 19th century, he devoted himself to raising the profile of these appellations. Since it was founded in 1881, the domaine has been managed by five generations of the same family. It currently makes prestigious appellations from its 50 hectares of vines, deliberately producing small quantities.