In 1880 Joseph Drouhin founded the eponymous wine merchant, but it was his son, Maurice, who after the First World War, started to buy some of the good parcels around Beaune, including the famous Clos des Mouches. Maurice's nephew, Robert, continued his uncle's good work and expanded the domain in to certain prestigious terrroirs, such as Musigny, Griotte-Chambertin, Chambertin-Clos de Bèze, Bonnes Mares, Grands Échézeaux, etc. A pioneer in vinification methods, he was one of the first winemakers in Burgundy to move towards sustainable farming principles: limited fertilisers and treatments, yield management, etc. The Joseph Drouhin house has been managed by Robert Drouhin's four children since 2003. This famous house in Beaune is internationally renowned and consists of 72 hectares of vineyard, divided in to 26 ha of red and 46 ha of white. It spreads from north to south between Chablis (38 hectares), Côte de Nuits and Côte de Beaune (30 hectares). In 1987 the Domaine also acquired vines in Orégon.

The Clos des Mouches of Joseph Drouhin comes from a hillside vineyard facing south. The winemakers put their hives at this place before. Bees were call flies before, hence the name of the place, "La Mouche". Produced on six and a half hectares, this prestigious white wine made with Chardonnay selections. Its color is a pale gold, very bright. The aromas remind honey, almond and lemongrass with, ageing, intense flavours of hazelnut and roasted almond. It is very persistent in the mouth.